membrane reconstitution


Advances in imaging, genetics, and sequencing have made it possible to identify, track, and manipulate molecules involved in many different cellular processes. However, still missing is the ability to recapitulate the spatial organization and dynamic properties of living cells – a challenge that requires encapsulation within or close proximity to a lipid bilayer membrane. Through the use of a variety of approaches and new technologies, we are studying how proteins organize and shape membranes, as well as how membranes and compartmentalization influence proteins and their interactions. The knowledge gained through these fundamental studies provides a foundation for building “cell-like” systems from the bottom-up, component by component.


Mike Vahey           Matt Good
Arunan Skandarajah     Eva Schmid