Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion
Nature Cell Biology (2018); DOI: 10.1038/s41556-018-0106-3
Duan R, Kim JH, Shilagardi K, Schiffhauer ES, Lee DM, Son S, Li S, Thomas C, Luo T, Fletcher DA, Robinson DN, Chen EH
Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling
eLife (2018); DOI: 10.7554/eLife.26161
Ricca BL*, Venugopalan G*, Furuta S, Tanner K, Orellana WA, Reber CD, Brownfield DG, Bissell MJ, Fletcher DA
Force-induced transcellular tunnel formation in endothelial cells
Molecular Biology of the Cell (2017); DOI: 10.1091/mbc.E17-01-0080
Ng WP, Webster KD, Stefani C, Schmid EM, Lemichez E, Bassereau, Fletcher DA
Organ sculpting by patterned extracellular matrix stiffness
eLife (2017); DOI: 10.7554/eLife.24958.001
Crest J, Diz- Muñoz A, Chen DY, Fletcher DA, Bilder D
Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration
PLoS Biology (2016); DOI: 10.1371/journal.pbio.1002474
Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD
Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase
J Cell Biol. 209(2), 275-88 (2015)
S.S. Lou, A. Diz-Muñoz, O.D. Weiner, D.A. Fletcher, J.A. Theriot
Mechanical tension drives cell membrane fusion
Dev Cell. 32(5), 561-73 (2015)
J.H. Kim, Y. Ren, W.P. Ng, S. Li, S. Son, Y.S. Kee, S. Zhang, G. Zhang, D.A. Fletcher, D.N. Robinson, E.H. Chen
Multicellular architecture of malignant breast epithelia influences mechanics
PLoS ONE. 9, e101955 (2014)
G. Venugopalan, D.B. Camarillo, K.D. Webster, C.D. Reber, J.A. Sethian, V.M. Weaver, D.A. Fletcher, H. El-Samad, C.H. Rycroft
Tensional homeostasis in single fibroblasts
Biophys. J. 107, 146–155 (2014)
K.D. Webster, W.P. Ng, D.A. Fletcher
Dynamic mechanical responses of Arabidopsis thylakoid membranes during PSII-specific illumination
Biophys. J. 106, 1864–1870 (2014)
C.H. Clausen, M.D. Brooks, T.D. Li, P. Grob, G Kemalyan, E. Nogales, K.K. Niyogi, D.A. Fletcher
Placental syncytium forms a biophysical barrier against pathogen invasion
PLoS Pathog. 9, e1003821 (2013)
V.B. Zeldovich, C.H. Clausen, E. Bradford, D.A. Fletcher, E. Maltepe, J.R. Robbins, A.I. Bakardjiev
A multi-structural single cell model of force-induced interactions of cytoskeletal components
Biomaterials. 34, 6119–6126 (2013)
S. Barreto, C.H. Clausen, C.M. Perrault, D.A. Fletcher, D. Lacroix
Patterned Collagen Fibers Orient Branching Mammary Epithelium through Distinct Signaling Modules
Curr. Biol. 23, 703–709 (2013)
D.G. Brownfield, G. Venugopalan, A. Lo, H. Mori, K. Tanner, D.A. Fletcher, M.J. Bissell
Contractile equilibriation of single cells to step changes in extracellular stiffness
Biophys. J. 102, 443–451 (2012)
A. Crow, K.D. Webster, E. Hohlfeld, W.P. Ng, P. Geissler, D.A. Fletcher
In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology
J. Clin. Invest. 122, 408–418 (2012)
M. Tsai, A. Kita, J. Leach, R. Rounsevell, J.N. Huang, J. Moake, R.E. Ware, D.A. Fletcher, W.A. Lam
Microenvironmental geometry guides platelet adhesion and spreading: A quantitative analysis at the single cell level
PLoS ONE. 6, e26437 (2011)
A. Kita, Y. Sakuri, D.R. Myers, R. Rounsevell, J.N. Huang, T.J. Seok, K. Yu, M.C. Wu, D.A. Fletcher, W.A. Lam
An AFM-based stiffness clamp for dynamic control of rigidity
PLoS ONE. 6, e17807 (2011)
K. Webster, A. Crow, D.A. Fletcher
On force and function
Mol. Biol. Cell. 21, 3795–3796 (2010)
D.A. Fletcher
Large-scale simulations of fluctuating biological membranes
J Chem Phys. 132, 154107 (2010)
A. Pasqua, L. Maibaum, G. Oster, D.A. Fletcher
Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function
Mol Cell Biomech. 3, 91–105 (2010)
G. Bao, R.D. Kamm, W. Thomas, W. Hwang, D.A. Fletcher, A.J. Grodzinsky, C. Zhu, M.R. Mofrad
Cell mechanics and the cytoskeleton
Nature. 463, 485–492 (2010)
D.A. Fletcher and R.D. Mullins
Active biological materials
Annu Rev Phys Chem. 60, 469–486 (2009)
D.A. Fletcher and P.L. Geissler
Combined atomic force microscopy and side-view optical imaging for mechanical studies of cells
Nat. Methods. 6, 383–387 (2009)
O. Chaudhuri, S.H. Parekh, W.A. Lam, D.A. Fletcher
Slow Stress Propagation in Adherent Cells
Biophys. J. 95, 6052–6059 (2008)
M.J. Rosenbluth, A. Crow, J.W. Shaevitz, D.A. Fletcher
DNA-coated AFM cantilevers for the investigation of cell adhesion and the patterning of live cells
Angew. Chem. Int. Ed. Engl. 47, 8473–8477 (2008)
S.C. Hsiao, A.K. Crow, W.A. Lam, C.R. Bertozzi, D.A. Fletcher, M.B. Francis
Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry
Lab Chip. 8, 1062–1070 (2008)
M.J. Rosenbluth, W.A. Lam, D.A. Fletcher
Limits of filipodium stability
Phys. Rev. Lett. 100, 258102 (2008)
S. Pronk, P.L. Geissler, D.A. Fletcher
Curvature and torsion in growing actin networks
Phys Biol. 5, 026006 (2008)
J.W. Shaevitz, D.A. Fletcher
Increased leukaemia cell stiffness is associated with symptoms of leucostasis in paediatric acute lymphoblastic leukaemia
Br. J. Haematol. 142, 497–501 (2008)
W.A. Lam, M.J. Rosenbluth, D.A. Fletcher
Tonic shock induces detachment of Giardia lamblia
PLoS Negl Trop Dis. 2, e169 (2008)
W.R. Hansen, D.A. Fletcher
Load fluctuations drive actin network growth
Proc. Natl. Acad. Sci. U.S.A. 104, 15688–15692 (2007)
J.W. Shaevitz, D.A. Fletcher
Emergence of large-scale cell morphology and movement from local actin filament growth dynamics
PLoS Biol. 5, e233 (2007)
C.I. Lacayo, Z. Pincus, M.M. van Duijn, C.A. Wilson, D.A. Fletcher, F.B. Gertler, A. Mogilner, J.A. Theriot
Chemotherapy exposure increases leukemia cell stiffness
Blood. 109, 3505–3508 (2007)
W.A. Lam, M.J. Rosenbluth, and D.A. Fletcher
Reversible stress softening of actin networks
Nature. 445, 295–298 (2007)
O.Chaudhuri, S.H. Parekh, and D.A. Fletcher
Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures
Science. 314, 298–300 (2006)
C.M. Nelson, M.M. Van Duijn, J.L. Inman, D.A. Fletcher, and M.J. Bissell
Giardia lamblia Attachment Force is Insensitive to Surface Treatments
Eukaryotic Cell. 5, 781–783 (2006)
W.R. Hansen, O Tulyathan, S.C. Dawson, W.Z. Cande, and D. A. Fletcher
Force microscopy of nonadherent cells: A comparison of leukemia cell deformability
Biophys. J. 90, 2994–3003 (2006)
M.J. Rosenbluth, W.A. Lam, and D.A. Fletcher
Loading history determines velocity of actin network growth
Nat. Cell Biol. 7, 1219–1223 (2005)
S.H. Parekh, O. Chaudhuri, J. Theriot, and D.A. Fletcher
Spiroplasma Swim by a Processive Change in Body Helicity
Cell. 122, 941–945 (2005)
J.W. Shaevitz, J.Y. Lee, D.A. Fletcher
Differentiation and developmental pathways of uropathogenic E. coli in urinary tract pathogenesis
Proc. Natl. Acad. Sci. U.S.A. 101, 1333–1338 (2004)
S.S. Justice, C. Hung, J.A. Theriot, D.A. Fletcher, G.G. Anderson, M.J. Footer, and S.J. Hultgren
Compression forces generated by actin comet tails on lipid vesicles
Proc. Natl. Acad. Sci. U.S.A. 100, 6493–6498 (2003)
P.A. Giardini, D.A. Fletcher, J.A. Theriot
Mailing Address: 731 Stanley Hall, Berkeley, CA, 94720, USA
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