In pursuit of the mechanics that shape cell surfaces

Nature Physics (2018); 14, 648–652
Diz-Muñoz A, Weiner DO, Fletcher DA

Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion.
Nat Cell Biol. (2018) Jun; doi: 10.1038/s41556-018-0106-3.
Duan R, Kim JH, Shilagardi K, Schiffhauer ES, Lee DM, Son S, Li S, Thomas C, Luo T, Fletcher DA, Robinson DN, Chen EH.

Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling.
Elife. (2018) e26161. doi: 10.7554/eLife.26161.
Ricca BL, Venugopalan G, Furuta S, Tanner K, Orellana WA, Reber CD, Brownfield DG, Bissell MJ, Fletcher DA.

Force-induced transcellular tunnel formation in endothelial cells.
Mol Biol Cell. doi: 10.1091/mbc.E17-01-0080. [Epub ahead of print] (2017)
Ng WP, Webster KD, Stefani C, Schmid EM, Lemichez E, Bassereau, Fletcher DA

Organ sculpting by patterned extracellular matrix stiffness.
Elife. 27;6 (2017)
Crest J, Diz- Muñoz A, Chen DY, Fletcher DA, Bilder D

Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration
PLoS Biol. 14(6), eCollection (2016)
Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD

Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase
J Cell Biol. 209(2), 275-88 (2015)
S.S. Lou, A. Diz-Muñoz, O.D. Weiner, D.A. Fletcher, J.A. Theriot

Mechanical tension drives cell membrane fusion
Dev Cell. 32(5), 561-73 (2015)
J.H. Kim, Y. Ren, W.P. Ng, S. Li, S. Son, Y.S. Kee, S. Zhang, G. Zhang, D.A. Fletcher, D.N. Robinson, E.H. Chen

Multicellular architecture of malignant breast epithelia influences mechanics
PLoS ONE. 9, e101955 (2014)
G. Venugopalan, D.B. Camarillo, K.D. Webster, C.D. Reber, J.A. Sethian, V.M. Weaver, D.A. Fletcher, H. El-Samad, C.H. Rycroft

Tensional homeostasis in single fibroblasts
Biophys. J. 107, 146–155 (2014)
K.D. Webster, W.P. Ng, D.A. Fletcher

Dynamic mechanical responses of Arabidopsis thylakoid membranes during PSII-specific illumination
Biophys. J. 106, 1864–1870 (2014)
C.H. Clausen, M.D. Brooks, T.D. Li, P. Grob, G Kemalyan, E. Nogales, K.K. Niyogi, D.A. Fletcher

Placental syncytium forms a biophysical barrier against pathogen invasion
PLoS Pathog. 9, e1003821 (2013)
V.B. Zeldovich, C.H. Clausen, E. Bradford, D.A. Fletcher, E. Maltepe, J.R. Robbins, A.I. Bakardjiev

To pull or be pulled: parsing the multiple modes of mechanotransduction
Curr. Opin. Cell Biol. 25, 558–564 (2013)
B.L. Ricca, G. Venugopalan, D.A. Fletcher

A multi-structural single cell model of force-induced interactions of cytoskeletal components
Biomaterials. 34, 6119–6126 (2013)
S. Barreto, C.H. Clausen, C.M. Perrault, D.A. Fletcher, D. Lacroix

Patterned Collagen Fibers Orient Branching Mammary Epithelium through Distinct Signaling Modules
Curr. Biol. 23, 703–709 (2013)
D.G. Brownfield, G. Venugopalan, A. Lo, H. Mori, K. Tanner, D.A. Fletcher, M.J. Bissell

Use the force: membrane tension as an organizer of cell shape and motility
Trends Cell Biol. 23, 47–53 (2013)
A. Diz-Muñoz, D.A. Fletcher, O.D. Weiner

Contractile equilibriation of single cells to step changes in extracellular stiffness
Biophys. J. 102, 443–451 (2012)
A. Crow, K.D. Webster, E. Hohlfeld, W.P. Ng, P. Geissler, D.A. Fletcher

Microenvironmental geometry guides platelet adhesion and spreading: A quantitative analysis at the single cell level
PLoS ONE. 6, e26437 (2011)
A. Kita, Y. Sakuri, D.R. Myers, R. Rounsevell, J.N. Huang, T.J. Seok, K. Yu, M.C. Wu, D.A. Fletcher, W.A. Lam

On force and function
Mol. Biol. Cell. 21, 3795–3796 (2010)
D.A. Fletcher

Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function
Mol Cell Biomech. 3, 91–105 (2010)
G. Bao, R.D. Kamm, W. Thomas, W. Hwang, D.A. Fletcher, A.J. Grodzinsky, C. Zhu, M.R. Mofrad

Cell mechanics and the cytoskeleton
Nature. 463, 485–492 (2010)
D.A. Fletcher and R.D. Mullins

Active biological materials
Annu Rev Phys Chem. 60, 469–486 (2009)
D.A. Fletcher and P.L. Geissler

Slow Stress Propagation in Adherent Cells
Biophys. J. 95, 6052–6059 (2008)
M.J. Rosenbluth, A. Crow, J.W. Shaevitz, D.A. Fletcher

Limits of filipodium stability
Phys. Rev. Lett. 100, 258102 (2008)
S. Pronk, P.L. Geissler, D.A. Fletcher

Increased leukaemia cell stiffness is associated with symptoms of leucostasis in paediatric acute lymphoblastic leukaemia
Br. J. Haematol. 142, 497–501 (2008)
W.A. Lam, M.J. Rosenbluth, D.A. Fletcher

Tonic shock induces detachment of Giardia lamblia
PLoS Negl Trop Dis. 2, e169 (2008)
W.R. Hansen, D.A. Fletcher

Emergence of large-scale cell morphology and movement from local actin filament growth dynamics
PLoS Biol. 5, e233 (2007)
C.I. Lacayo, Z. Pincus, M.M. van Duijn, C.A. Wilson, D.A. Fletcher, F.B. Gertler, A. Mogilner, J.A. Theriot

Chemotherapy exposure increases leukemia cell stiffness
Blood. 109, 3505–3508 (2007)
W.A. Lam, M.J. Rosenbluth, and D.A. Fletcher

Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures
Science. 314, 298–300 (2006)
C.M. Nelson, M.M. Van Duijn, J.L. Inman, D.A. Fletcher, and M.J. Bissell

Giardia lamblia Attachment Force is Insensitive to Surface Treatments
Eukaryotic Cell. 5, 781–783 (2006)
W.R. Hansen, O Tulyathan, S.C. Dawson, W.Z. Cande, and D. A. Fletcher

Force microscopy of nonadherent cells: A comparison of leukemia cell deformability
Biophys. J. 90, 2994–3003 (2006)
M.J. Rosenbluth, W.A. Lam, and D.A. Fletcher

Spiroplasma Swim by a Processive Change in Body Helicity
Cell. 122, 941–945 (2005)
J.W. Shaevitz, J.Y. Lee, D.A. Fletcher

An introduction to cell motility for the physical scientist
Phys Biol. 1, T1–10 (2004)
D. A. Fletcher and J. A. Theriot

Differentiation and developmental pathways of uropathogenic E. coli in urinary tract pathogenesis
Proc. Natl. Acad. Sci. U.S.A. 101, 1333–1338 (2004)
S.S. Justice, C. Hung, J.A. Theriot, D.A. Fletcher, G.G. Anderson, M.J. Footer, and S.J. Hultgren