Publications
Target cell cortical tension regulates macrophage trogocytosis
Nature Cell Biology (2025); DOI: 10.1038/s41556-025-01807-6
Cornell CE, Chorlay A, Krishnamurthy D, Martin NR, Baldauf L, Fletcher DA
SurFlex microscopy: Measuring flexibility of surface-tethered biomolecules
PNAS (2025); DOI: 10.1073/pnas.2508828122
Chorlay A, Agarwal S, Blackmon L, Dextre A, Fletcher DA
Cell surface crowding is a tunable energetic barrier to cell-cell fusion
Nature Communications (2025); DOI: 10.1038/s41467-025-62330-8
Lee DSW*, Oster LF*, Son S, Fletcher DA
Multi-contrast machine learning improves schistosomiasis diagnostic performance
PLoS Neglected Tropical Diseases (2025); DOI: 10.1371/journal.pntd.0012879
Díaz de León Derby M, Delahunt CB, Spencer E, Coulibaly JT, Silue KD, Bogoch II, Ny A-LL, Fletcher DA
Challenges of microscopy technology dissemination to resource-constrained communities
Nature Methods (2025); DOI: 10.1038/s41592-025-02690-7
Aaron JS, Jacobs AC, Malacrida L, Keppler A, French P, Fletcher DA, Wood C, Brown CM, Wright GD, Ogawa S, Maina M, Chew T-L
Kinetics and Optimality of Influenza A Virus Locomotion
Physical Review Letters (2024); DOI: 10.1103/PhysRevLett.133.248402
Agarwal S, Veytsman B, Fletcher DA, Huber G
Engineered molecular sensors for quantifying cell surface crowding
PNAS (2023); DOI: 10.1073/pnas.2219778120
Takatori SC*, Son S*, Lee DSW, Fletcher DA
Programming multicellular assembly with synthetic cell adhesion molecules
Nature (2022); DOI: 10.1038/s41586-022-05622-z
Stevens AJ, Harris AR, Gerdts J, Kim KH, Trentesaux C, Ramirez JT, McKeithan WL, Fattahi F, Klein OD, Fletcher DA, Lim WA
The molecular mechanism of load adaptation by branched actin networks
eLife (2022); DOI: 10.7554/eLife.73145
Li TD*, Bieling P*, Weichsel J, Mullins RD, Fletcher DA
Point-of-Care Sample Preparation and Automated Quantitative Detection of Schistosoma haematobium Using Mobile Phone Microscopy
American Journal of Tropical Medicine and Hygiene (2022); DOI: 10.4269/ajtmh.21-1071
Armstrong M, Harris AR, D’Ambrosio MV, Coulibaly JT, Essien-Baidoo S, Ephraim RKD, Andrews JR, Bogoch II, Fletcher DA
Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy
Cell (2021); DOI: 10.1016/j.cell.2020.12.001
Fozouni P*, Son S*, Díaz de León Derby M*, Knott GJ, Gray CN, D’Ambrosio MV, Zhao C, Switz NA, Kumar GR, Stephens SI, Boehm D, Tsou CL, Shu J, Bhuiya A, Armstrong M, Harris A, Osterloh JM, Meyer-Franke A, Langelier C, Pollard KS, Crawford ED, Puschnik AS, Phelps M, Kistler A, DeRisi JL, Doudna JA, Fletcher DA, Ott M
Evolutionarily related small viral fusogens hijack distinct but modular actin nucleation pathways to drive cell-cell fusion
PNAS (2021); DOI: 10.1073/pnas.2007526118
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Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation
Cell Reports (2021); DOI: 10.1016/j.celrep.2021.109587
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Cell–cell interfaces as specialized compartments directing cell function
Nature Reviews Molecular Cell Biology (2020); DOI: 10.1038/s41580-020-00298-7
, Son S, Felce JH, Dustin ML,
Forming and loading giant unilamellar vesicles with acoustic jetting
Biomicrofluidics (2020); DOI: 10.1063/5.0021742
Armstrong M, Vahey MD, Hunt TP, Fletcher DA
A Weak Link with Actin Organizes Tight Junctions to Control Epithelial Permeability
Developmental Cell (2020); DOI: 10.1016/j.devcel.2020.07.022
, Hamkins-Indik T*, Harris AR, Kim J, Xu K,
Macrophage phagocytosis assay with reconstituted target particles
Nature Protocols (2020); DOI: 10.1038/s41596-020-0330-8
Joffe AM, Bakalar MH, Fletcher DA
Molecular height measurement by cell surface optical profilometry (CSOP)
PNAS (2020); DOI: 10.1073/pnas.1922626117
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Biased localization of actin binding proteins by actin filament conformation
Nature Communications (2020); DOI: 10.1038/s41467-020-19768-9
Harris AR, Jreij P, Belardi B, Joffe AM, Bausch AR, Fletcher DA
Microscale fluid behavior during cryo-EM sample blotting
Biophysical Journal (2020); DOI: 10.1016/j.bpj.2019.12.017
Armstrong M, Han B-G, Gomez S, Turner J, Fletcher DA, Glaeser RM
A viral fusogen hijacks the actin cytoskeleton to drive cell-cell fusion
eLife (2020); DOI: 10.7554/eLife.51358
Chan KMC, Son S, Schmid EM, Fletcher DA
Steric Regulation of Tandem Calponin Homology Domain Actin-Binding Affinity
Molecular Biology of the Cell (2019); DOI: 10.1091/mbc.E19-06-0317
Harris AR, Belardi B, Jreij P, Wei K, Shams H, Bausch A, Fletcher DA
Deep learning for single-shot autofocus microscopy
Optica (2019); DOI: 10.1364/OPTICA.6.000794
Pinkard H, Phillips Z, Babakhani A, Fletcher DA, Waller L
Smartphone-Based, Rapid, Wide-Field Fundus Photography for Diagnosis of Pediatric Retinal Diseases
Translational Vision Science & Technology (2019); DOI: 10.1167/tvst.8.3.29
Patel TP, Kim TN, Yu G, Dedania VS, Lieu P, Qian CX, Besirli CG, Demirci H, Margolis T, Fletcher DA, Paulus YM
Influenza A virus surface proteins are organized to help penetrate host mucus
eLife (2019); DOI: 10.7554/eLife.43764
Vahey MD, Fletcher DA
Stiffness Sensing by Cells
Physiological Reviews (2019); DOI: 10.1152/physrev.00013.2019
In pursuit of the mechanics that shape cell surfaces
Nature Physics (2018); DOI: 10.1038/s41567-018-0187-8
Diz-Muñoz A, Weiner DO, Fletcher DA
Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane
Journal of Biological Chemistry (2018); DOI: 10.1074/jbc.RA118.005669
Lakshman B, Messing S, Schmid EM, Clogston JD, Gillette WK, Esposito D, Kessing B, Fletcher DA, Nissley DV, McCormick F, Stephen AG, Jean-Francois FL
Low-Fidelity Assembly of Influenza A Virus Promotes Escape from Host Cells
Cell (2018); DOI: 10.1016/j.cell.2018.10.056
Vahey MD, Fletcher DA
Which biological systems should be engineered?
Nature (2018)
Fletcher DA
From solution to surface to filament: actin flux into branched networks
Biophysical Reviews (2018); DOI: 10.1007/s12551-018-0469-5
Mullins RD, Bieling P, Fletcher DA
A Smartphone-Based Tool for Rapid, Portable, and Automated Wide-Field Retinal Imaging
Translational Vision Science & Technology (2018); DOI: 10.1167/tvst.7.5.21
Kim TN, Myers F, Reber C, Loury PJ, Loumou P, Webster D, Echanique C, Li P, Davila JR, Maamari RN, Switz NA, Keenan J, Woodward MA, Paulus YM, Margolis T, Fletcher DA
Mechanotransduction by the Actin Cytoskeleton: Converting Mechanical Stimuli into Biochemical Signals
Annual Review of Biophysics (2018); DOI: 10.1146/annurev-biophys-070816-033547
Harris AR, Jreij P, Fletcher DA.
One and one is not two: taking a fresh look at membrane interfaces
Nature Reviews Molecular Cell Biology (2018); DOI: 10.1038/s41580-018-0057-3
Belardi B, Fletcher DA
Claudin-4 reconstituted in unilamellar vesicles is sufficient to form tight interfaces that partition membrane proteins
Journal of Cell Science (2018); DOI: 10.1242/jcs.221556
Belardi B, Son S, Vahey MD, Wang J, Hou J, Fletcher DA
Size-Dependent Segregation Controls Macrophage Phagocytosis of Antibody-Opsonized Targets
Cell (2018); DOI: 10.1016/j.cell.2018.05.059
Bakalar MH, Joffe AM, Schmid EM, Son S, Podolski M, Fletcher DA
Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion
Nature Cell Biology (2018); DOI: 10.1038/s41556-018-0106-3
Duan R, Kim JH, Shilagardi K, Schiffhauer ES, Lee DM, Son S, Li S, Thomas C, Luo T, Fletcher DA, Robinson DN, Chen EH
Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling
eLife (2018); DOI: 10.7554/eLife.26161
Ricca BL*, Venugopalan G*, Furuta S, Tanner K, Orellana WA, Reber CD, Brownfield DG, Bissell MJ, Fletcher DA
In Southern Nigeria Loa loa Blood Microfilaria Density is Very Low Even in Areas with High Prevalence of Loiasis: Results of a Survey Using the New LoaScope Technology
American Journal of Tropical Medicine and Hygiene (2018); DOI: 10.4269/ajtmh.18-0163
Emukah E, Rakers LJ, Kahansim B, Miri ES, Nwoke BEB, Griswold E, Saka Y, Anagbogu I, Davies E, Ityonzughul C, D’Ambrosio M, Bakalar M, Fletcher DA, Nutman T, Kamgno J, Richards FO
A Test-and-Not-Treat Strategy for Onchocerciasis in Loa loa–Endemic Areas
New England Journal of Medicine (2017); DOI: 10.1056/NEJMoa1705026
Kamgno J, Pion SD, Chesnais CB, Bakalar MH, D’Ambrosio MV, Mackenzie CD, Nana-Djeunga HC, Gounoue-Kamkumo R, Njitchouang GR, Nwane P, Tchatchueng-Mbouga JB, Wanji S, Stolk WA, Fletcher DA, Klion AD, Nutman TB, and Boussinesq M
Force-induced transcellular tunnel formation in endothelial cells
Molecular Biology of the Cell (2017); DOI: 10.1091/mbc.E17-01-0080
Ng WP, Webster KD, Stefani C, Schmid EM, Lemichez E, Bassereau, Fletcher DA
Organ sculpting by patterned extracellular matrix stiffness
eLife (2017); DOI: 10.7554/eLife.24958.001
Crest J, Diz- Muñoz A, Chen DY, Fletcher DA, Bilder D
Bottom-Up Biology: Harnessing Engineering to Understand Nature
Developmental Cell (2016); DOI: 10.1016/j.devcel.2016.09.009
Fletcher DA
Accuracy of Mobile Phone and Handheld Light Microscopy for the Diagnosis of Schistosomiasis and Intestinal Protozoa Infections in Côte d’Ivoire
PLoS Neglected Tropical Diseases (2016); DOI: 10.1371/journal.pntd.0004768
Coulibaly JT, Ouattara M, D’Ambrosio MV, Fletcher DA, Keiser J, Utzinger J, N’Goran EK, Andrews JR, Bogoch II
Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration
PLoS Biology (2016); DOI: 10.1371/journal.pbio.1002474
Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD
Size-dependent protein segregation at membrane interfaces
Nature Physics (2016); DOI: 10.1038/nphys3678
Schmid EM*, Bakalar MH*, Choudhuri K*, Weichsel J, Ann HS, Geissler PL, Dustin ML, Fletcher DA
Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks
Cell (2016); DOI: 10.1016/j.cell.2015.11.057
Bieling P*, Li TD*, Weichsel J, McGorty R, Jreij P, Huang B, Fletcher DA, Mullins RD
Evaluation of mobile digital light-emitting diode fluorescence microscopy in Hanoi, Viet Nam
International Journal of Tuberculosis and Lung Disease (2015); DOI: 10.5588/ijtld.15.0018
Chaisson LH, Reber C, Phan H, Switz N, Nilsson LM, Myers F, Nhung NV, Luu L, Pham T, Vu C, Nguyen H, Nguyen A, Dinh T, Nahid P, Fletcher DA, Cattamanchi A
Assessment of a Smartphone Otoscope Device for the Diagnosis and Management of Otitis Media
Clin Pediatr (Phila). pii: 0009922815593909. [Epub ahead of print], (2015)
Rappaport KM, McCracken CC, Beniflah J, Little WK, Fletcher DA, Lam WA, Shane AL.
Reconstitution of proteins on electroformed unilamellar vesicles
Methods Cell Biol. 128:319-38. (2015)
E.M. Schmid, D.L. Richmond, D.A. Fletcher
Multi-Contrast Imaging and Digital Refocusing on a Mobile Microscope with a Domed LED Array
PLoS One. 10(5), eCollection (2015)
Phillips ZF, D’Ambrosio MV, Tian L, Rulison JJ, Patel HS, Sadras N, Gande AV, Switz NA, Fletcher DA, Waller L.
Point-of-care quantification of blood-borne filarial parasites with a mobile phone microscope
Sci Transl Med. 7(286), 286re4. (2015)
M.V. D’Ambrosio, M. Bakalar, S. Bennuru, C. Reber, A. Skandarajah, L. Nilsson, N. Switz, J. Kamgno, S. Pion, M. Boussinesq, T.B. Nutman, D.A. Fletcher
Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase
J Cell Biol. 209(2), 275-88 (2015)
S.S. Lou, A. Diz-Muñoz, O.D. Weiner, D.A. Fletcher, J.A. Theriot
Diagnosis of Schistosoma haematobium Infection with a Mobile Phone-Mounted Foldscope and a Reversed-Lens CellScope in Ghana
Am J Trop Med Hyg. 14-0741 Epub ahead of print (2015)
R.K. Ephraim, E. Duah, J.S. Cybulski, M. Prakash, M.V. D’Ambrosio, D.A. Fletcher, J. Keiser, J.R. Andrews, I.I. Bogoch
Mechanical tension drives cell membrane fusion
Dev Cell. 32(5), 561-73 (2015)
J.H. Kim, Y. Ren, W.P. Ng, S. Li, S. Son, Y.S. Kee, S. Zhang, G. Zhang, D.A. Fletcher, D.N. Robinson, E.H. Chen
A lateral electrophoretic flow diagnostic assay
Lab Chip. 15, 1488-1496 (2015)
R. Lin, A. Skandarajah, R.E. Gerver, H.D. Neira, D.A. Fletcher, A.E. Herr
Multicellular architecture of malignant breast epithelia influences mechanics
PLoS ONE. 9, e101955 (2014)
G. Venugopalan, D.B. Camarillo, K.D. Webster, C.D. Reber, J.A. Sethian, V.M. Weaver, D.A. Fletcher, H. El-Samad, C.H. Rycroft
Novel telemedicine device for diagnosis of corneal abrasions and ulcers in resource-poor settings
JAMA Ophthalmol. 132, 894–895 (2014)
R.N. Maamari, S. Ausayakhun, T.P. Margolis, D.A. Fletcher, J.D. Keenan
Tensional homeostasis in single fibroblasts
Biophys. J. 107, 146–155 (2014)
K.D. Webster, W.P. Ng, D.A. Fletcher
Low-cost mobile phone microscopy with a reversed mobile phone camera lens
PLoS ONE. 9, e95330 (2014)
N.A. Switz, M.V. D’Ambrosio, D.A. Fletcher
Dynamic mechanical responses of Arabidopsis thylakoid membranes during PSII-specific illumination
Biophys. J. 106, 1864–1870 (2014)
C.H. Clausen, M.D. Brooks, T.D. Li, P. Grob, G Kemalyan, E. Nogales, K.K. Niyogi, D.A. Fletcher
Quantitative imaging with a mobile phone microscope
PLoS ONE. 9, e96906 (2014)
A. Skandarajah, C.D. Reber, N.A. Switz, D.A. Fletcher
Lipid bilayer vesicle generation using microfluidic jetting
J Vis Exp. 84, e51510 (2014). doi:10.3791/51510
C.W. Coyne, K. Patel, J. Heureaux, J. Stachowiak, D.A. Fletcher, A.P. Liu
Micropattern-guided assembly of overlapping pairs of dynamic microtubules
Meth. Enzymol. 540, 339–360 (2014)
F.J. Fourniol, T.D. Li, P. Bieling, R.D. Mullins, D.A. Fletcher, T. Surrey
Placental syncytium forms a biophysical barrier against pathogen invasion
PLoS Pathog. 9, e1003821 (2013)
V.B. Zeldovich, C.H. Clausen, E. Bradford, D.A. Fletcher, E. Maltepe, J.R. Robbins, A.I. Bakardjiev
A mobile phone-based retinal camera for portable wide field imaging
Br J Ophthalmol. 98, 438–441 (2014)
R.N. Maamari, J.D. Keenan, D.A. Fletcher, T.P. Margolis
The biology of boundary conditions: cellular reconstitution in one, two, and three dimensions
Curr. Opin. Cell Biol. 26, 60–68 (2014)
M.D. Vahey, D.A. Fletcher
Cytoplasmic volume modulates spindle size during embryogenesis
Science. 342, 856–860 (2013)
M.C. Good, M.D. Vahey, A. Skandarajah, D.A. Fletcher, R. Heald
To pull or be pulled: parsing the multiple modes of mechanotransduction
Curr. Opin. Cell Biol. 25, 558–564 (2013)
B.L. Ricca, G. Venugopalan, D.A. Fletcher
A multi-structural single cell model of force-induced interactions of cytoskeletal components
Biomaterials. 34, 6119–6126 (2013)
S. Barreto, C.H. Clausen, C.M. Perrault, D.A. Fletcher, D. Lacroix
Patterned Collagen Fibers Orient Branching Mammary Epithelium through Distinct Signaling Modules
Curr. Biol. 23, 703–709 (2013)
D.G. Brownfield, G. Venugopalan, A. Lo, H. Mori, K. Tanner, D.A. Fletcher, M.J. Bissell
Mobile Digital Fluorescence Microscopy for Diagnosis of Tuberculosis
J. Clin. Microbiol. 51, 1774–1778 (2013)
A. Tapley, N. Switz, C. Reber, J.L. Davis, C. Miller, J.B. Matovu, W. Worodria, L. Huang, D.A. Fletcher, A. Cattamanchi
Use the force: membrane tension as an organizer of cell shape and motility
Trends in Cell Biology (2013); DOI: 10.1016/j.tcb.2012.09.006
A. Diz-Muñoz, D.A. Fletcher, O.D. Weiner
Automated tuberculosis diagnosis using fluorescence images from a mobile microscope
Med Image Comput Comput Assist Interv. 15, 345-52 (2012)
J. Chang, P. Arbeláez, N. Switz, C. Reber, A. Tapley, J.L. Davis, A. Cattamanchi, D.A. Fletcher, J. Malik
Membrane bending by protein-protein crowding
Nat. Cell Biol. 14, 944–949 (2012)
J.C. Stachowiak, E.M. Schmid , C.J. Ryan, H.S. Ann, D.Y. Sasaki, M.B. Sherman, P.L. Geissler, D.A. Fletcher, C.C. Hayden
Contractile equilibriation of single cells to step changes in extracellular stiffness
Biophys. J. 102, 443–451 (2012)
A. Crow, K.D. Webster, E. Hohlfeld, W.P. Ng, P. Geissler, D.A. Fletcher
Actin filament curvature biases branching direction
Proc. Natl. Acad. Sci. U.S.A. 109, 2913–2918 (2012)
V.I. Risca, E.B. Wang, O. Chaudhuri, J.J. Chia, P.L. Geissler, D.A. Fletcher
In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology
J. Clin. Invest. 122, 408–418 (2012)
M. Tsai, A. Kita, J. Leach, R. Rounsevell, J.N. Huang, J. Moake, R.E. Ware, D.A. Fletcher, W.A. Lam
Microenvironmental geometry guides platelet adhesion and spreading: A quantitative analysis at the single cell level
PLoS ONE. 6, e26437 (2011)
A. Kita, Y. Sakuri, D.R. Myers, R. Rounsevell, J.N. Huang, T.J. Seok, K. Yu, M.C. Wu, D.A. Fletcher, W.A. Lam
Forming giant vesicles with controlled membrane composition, asymmetry, and contents
Proc. Natl. Acad. Sci. U.S.A. 108, 9431–9436 (2011)
D.L. Richmond, E.M. Schmid, S. Martens, J.C. Stachowiak, N. Liska, D.A. Fletcher
An AFM-based stiffness clamp for dynamic control of rigidity
PLoS ONE. 6, e17807 (2011)
K. Webster, A. Crow, D.A. Fletcher
Single-Cell multiplex gene detection and sequencing with microfluidically generated agarose emulsions
Angew. Chem. Int. Ed. Engl. 50, 390–395 (2011)
R. Novak, Y. Zeng, J. Shuga, G. Venugopalan, D.A. Fletcher, M.T. Smith, R.A. Mathies
Mechanics and contraction dynamics of single platelets and implications for clot stiffening
Nat Mater. 10, 61–66 (2011)
W.A. Lam, O.Chaudhuri, A. Crow, K.D. Webster, T. Li, A. Kita, J. Huang, D.A. Fletcher
On force and function
Mol. Biol. Cell. 21, 3795–3796 (2010)
D.A. Fletcher
Large-scale simulations of fluctuating biological membranes
J Chem Phys. 132, 154107 (2010)
A. Pasqua, L. Maibaum, G. Oster, D.A. Fletcher
Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function
Mol Cell Biomech. 3, 91–105 (2010)
G. Bao, R.D. Kamm, W. Thomas, W. Hwang, D.A. Fletcher, A.J. Grodzinsky, C. Zhu, M.R. Mofrad
Cell mechanics and the cytoskeleton
Nature. 463, 485–492 (2010)
D.A. Fletcher and R.D. Mullins
Biology under construction: in vitro reconstitution of cellular function
Nat. Rev. Mol. Cell Biol. 10, 644–650 (2009)
A.P. Liu and D.A. Fletcher
Mobile phone based clinical microscopy for global health applications
PLoS ONE. 4, e6320 (2009)
D.N. Breslauer, R.N. Maamari, N.A. Switz, W.A. Lam, D.A. Fletcher
Inkjet formation of unilamellar lipid vesicles for cell-like encapsulation
Lab Chip. 9, 2003–2009 (2009)
J.C. Stachowiak, D.L. Richmond, T.H. Li, F. Brochard-Wyart and D.A. Fletcher
Active biological materials
Annu Rev Phys Chem. 60, 469–486 (2009)
D.A. Fletcher and P.L. Geissler
Dynamic control of needle-free jet injection
J Control Release. 135, 104–112 (2009)
J.C. Stachowiak, T.H. Li, A. Arora, S. Mitragotri, D.A. Fletcher
Combined atomic force microscopy and side-view optical imaging for mechanical studies of cells
Nat. Methods. 6, 383–387 (2009)
O. Chaudhuri, S.H. Parekh, W.A. Lam, D.A. Fletcher
Mixing solutions in inkjet formed vesicles
Meth. Enzymol. 465, 75–94 (2009)
T.H. Li, J.C. Stachowiak, D.A. Fletcher
Slow Stress Propagation in Adherent Cells
Biophys. J. 95, 6052–6059 (2008)
M.J. Rosenbluth, A. Crow, J.W. Shaevitz, D.A. Fletcher
DNA-coated AFM cantilevers for the investigation of cell adhesion and the patterning of live cells
Angew. Chem. Int. Ed. Engl. 47, 8473–8477 (2008)
S.C. Hsiao, A.K. Crow, W.A. Lam, C.R. Bertozzi, D.A. Fletcher, M.B. Francis
Membrane-induced bundling of actin filaments
Nat Phys. 4, 789–793 (2008)
A.P. Liu, D.L. Richmond, L. Maibaum, S. Pronk, P.L. Geissler, D.A. Fletcher
Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry
Lab Chip. 8, 1062–1070 (2008)
M.J. Rosenbluth, W.A. Lam, D.A. Fletcher
Limits of filipodium stability
Phys. Rev. Lett. 100, 258102 (2008)
S. Pronk, P.L. Geissler, D.A. Fletcher
Curvature and torsion in growing actin networks
Phys Biol. 5, 026006 (2008)
J.W. Shaevitz, D.A. Fletcher
Increased leukaemia cell stiffness is associated with symptoms of leucostasis in paediatric acute lymphoblastic leukaemia
Br. J. Haematol. 142, 497–501 (2008)
W.A. Lam, M.J. Rosenbluth, D.A. Fletcher
Unilamellar vesicle formation and encapsulation by microfluidic jetting
Proc. Natl. Acad. Sci. U.S.A. 105, 4697–4702 (2008)
J.C. Stachowiak, D.L. Richmond, T.H. Li, A.P. Liu, S.H. Parekh, D.A. Fletcher
Tonic shock induces detachment of Giardia lamblia
PLoS Negl Trop Dis. 2, e169 (2008)
W.R. Hansen, D.A. Fletcher
Piezoelectric control of needle-free transdermal drug delivery
J Control Release. 124, 88–97 (2007)
J.C. Stachowiak, M.G. von Muhlen, T.H. Li, L. Jalilian, S.H. Parekh, D.A. Fletcher
Load fluctuations drive actin network growth
Proc. Natl. Acad. Sci. U.S.A. 104, 15688–15692 (2007)
J.W. Shaevitz, D.A. Fletcher
Enhanced three-dimensional deconvolution microscopy using a measured depth-varying point spread function
J Opt Soc Am A Opt Image Sci Vis. 24, 2622–2627 (2007)
J.W. Shaevitz, D.A. Fletcher
Emergence of large-scale cell morphology and movement from local actin filament growth dynamics
PLoS Biol. 5, e233 (2007)
C.I. Lacayo, Z. Pincus, M.M. van Duijn, C.A. Wilson, D.A. Fletcher, F.B. Gertler, A. Mogilner, J.A. Theriot
Differential force microscope for long time-scale biophysical measurements
Rev Sci Instrum. 78, 043711 (2007)
J.L. Choy, S.H. Parekh, O. Chaudhuri, A.P. Liu, C. Bustamante, M.J. Footer, J.A. Theriot, D.A. Fletcher
Chemotherapy exposure increases leukemia cell stiffness
Blood. 109, 3505–3508 (2007)
W.A. Lam, M.J. Rosenbluth, and D.A. Fletcher
Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets
Proc. Natl. Acad. Sci. U.S.A. 104, 4255–4260 (2007)
Arora A, Hakim I, Baxter J, Rathnasingham R, Srinivasan R, Fletcher DA, Mitragotri S.
Reversible stress softening of actin networks
Nature. 445, 295–298 (2007)
O.Chaudhuri, S.H. Parekh, and D.A. Fletcher
Actin polymerization serves as a membrane domain switch in model lipid bilayers
Biophys. J. 91, 4064–4070 (2006)
A.P. Liu and D.A.Fletcher
Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures
Science. 314, 298–300 (2006)
C.M. Nelson, M.M. Van Duijn, J.L. Inman, D.A. Fletcher, and M.J. Bissell
Fast, cheap, and somewhat in control
Genome Biol. 7, 114 (2006)
A.P. Arkin and D.A. Fletcher
Giardia lamblia Attachment Force is Insensitive to Surface Treatments
Eukaryotic Cell. 5, 781–783 (2006)
W.R. Hansen, O Tulyathan, S.C. Dawson, W.Z. Cande, and D. A. Fletcher
Force microscopy of nonadherent cells: A comparison of leukemia cell deformability
Biophys. J. 90, 2994–3003 (2006)
M.J. Rosenbluth, W.A. Lam, and D.A. Fletcher
Loading history determines velocity of actin network growth
Nat. Cell Biol. 7, 1219–1223 (2005)
S.H. Parekh, O. Chaudhuri, J. Theriot, and D.A. Fletcher
Spiroplasma Swim by a Processive Change in Body Helicity
Cell. 122, 941–945 (2005)
J.W. Shaevitz, J.Y. Lee, D.A. Fletcher
Photopatterning of actin filament structures
Nano Lett. 5, 625–628 (2005)
A.P. Liu, D.A.Fletcher
An introduction to cell motility for the physical scientist
Phys Biol. 1, T1–10 (2004)
D. A. Fletcher and J. A. Theriot
Differentiation and developmental pathways of uropathogenic E. coli in urinary tract pathogenesis
Proc. Natl. Acad. Sci. U.S.A. 101, 1333–1338 (2004)
S.S. Justice, C. Hung, J.A. Theriot, D.A. Fletcher, G.G. Anderson, M.J. Footer, and S.J. Hultgren
Thermal microscopy with a microfabricated solid immersion lens
Microscale Thermophysical Engineering. 7, 4 267-273 (2003)
D.A. Fletcher, G.S. Kino, and K.E. Goodson
Compression forces generated by actin comet tails on lipid vesicles
Proc. Natl. Acad. Sci. U.S.A. 100, 6493–6498 (2003)
P.A. Giardini, D.A. Fletcher, J.A. Theriot
Intravascular drug delivery with the pulsed liquid microjet
Arch. Ophthalmol. 120, 1206–1208 (2002)
D.A. Fletcher, D.V. Palanker, P. Huie, J. Miller, M.F. Marmor, and M.S. Blumenkranz
Micromachined silicon nitride solid immersion lens
JMEMS. 11, 470-478 (2002)
K.B. Crozier, D.A. Fletcher, G.S. Kino, and C.F. Quate
Microfabricated silicon solid immersion lens
JMEMS. 10, 450-459 (2001)
D.A. Fletcher, K.B. Crozier, K.W. Guarini, S.C. Minne, G.S. Kino, C.F. Quate, and K. E. Goodson
Refraction contrast imaging with a scanning microlens
Applied Physics Letters. 78, 3589-3591 (2001)
D.A. Fletcher, K.B. Crozier, C.F. Quate, G.S. Kino, K.E. Goodson, D. Simanovskii, and D.V. Palanker
Focusing in microlenses close to a wavelength in diameter
Opt Lett. 26, 399–401 (2001)
D.A. Fletcher, K.E. Goodson, and G.S. Kino
Pulsed liquid microjet for microsurgery
Applied Physics Letters. 78, 1933-1935 (2001)
D. A. Fletcher and D.V. Palanker
Near-field infrared imaging with a microfabricated solid immersion lens
Applied Physics Letters. 77, 2109-2111 (2000)
D.A. Fletcher, K.B. Crozier, G.S. Kino, C.F. Quate, K.E. Goodson, D. Simanovskii, and D.V. Palanker
Dual integrated actuators for extended range high speed atomic force microscopy
Applied Physics Letters. 75, 1637-1639 (1999)
T. Sulchek, S.C. Mines, J.D. Adams, D.A. Fletcher, A. Atalar, C.F. Quate, and D.M. Adderton